The following clinical studies used the SomnoDent MAS as its active treatment and looked at various aspects of the use of oral appliance therapy for OSA and its associated symptoms and complications.

• Naismith et al (2005) studied the effect of oral appliance therapy on neurobehavioral functioning in patients with ostructive sleep apnoea, one group fitted with a custom made SomnoDent splint, the other group with only an upper plate and so did not advance the lower jaw. They concluded that "Treatment with the manibular advancement splint results in improvements in self-reported sleepiness, fatigue/energy levels and vigilance/pyschomotor speed in patients with obstructive sleep apnoea."

• Gostopoulos, Kelly & Cistulli (2004) conducted a randomised controlled trial to investigate the short-term effect (4 weeks) of oral appliance therapy for obstructive sleep apnea on blood pressure using the SomnoDent splint as the active treatment. They concluded that "oral appliance therapy for obstructive sleep apnoea over 4 weeks results in a reduction of blood pressure similar to that reported with continuous positive airway pressure."
  

• Gostopoulos et al (2002) aimed to evaluate the effectiveness of a custom made mandibular advancement splint (the SomnoDent) in 73 patients in treating variety of OSA symptoms. The study found that "4 weeks of MAS therapy improves daytime sleepiness and a range of other symptoms associated with OSA."

• Ng et al (2003) studies the effect of oral appliance therapy on upper airway collapsibility in obstructive sleep apnoea using the SomnoDent splint. The study found that this type of mandibular advancement device was well tolerated and "improved upper airway collapsibility during sleep in patients with OSA".